Natural killer (NK) cells are your allies when it comes to fighting infections and cancer.
The more we can understand what drives these cells, the better we can program them to fight disease.
NK cells are primed from birth to recognize and respond to danger. Learning what fuels NK cells is an active area of research in immunology, with important clinical implications.
At MSK Researchers and elsewhere has shown that T cells rely on aerobic glycolysis to carry out their protective functions.
NK cells depend on this form of metabolism to power their own activities was not known.
Dr. Sun and his colleagues studied NK cells in animalsThey found that NK cells ramp up aerobic glycolysis about five days prior to when T cells respond with their own glycolytic surge.
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